Synthesis, Characterization, and Bioactivity of Quinoxaline Thiazolotriazoles

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Hybrid quinoxaline thiazolotriazoles display antibacterial and antidiabetic properties, suggesting potential bioactivity.

Compound 4g shows the highest antibacterial and antidiabetic activity among the synthesized quinoxaline derivatives.
The most potent antibacterial compound, 4a, showed activity against six bacterial strains with MICs ranging from 176 to 352 μM.
A series of ten quinoxaline thiazolotriazole hybrids were synthesized and characterized, with several compounds displaying notable bioactivity.
Five compounds were active against α‐amylase, with IC50 values between 186 and 293 μM, indicating potential therapeutic use.

Mhlongo et al. (2025) studied this question.

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