September 11, 2025PLoS ONEOpen Access

Global, regional, and national burdens of five main digestive system cancers in adolescents and young adults from 1990 to 2021 based on the Global Burden of Disease Study 2021: A cross-sectional study

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Discussion

Cross-sectional study evaluates increasing colorectal cancer burdens in adolescents and young adults, suggesting targeted prevention strategies.

Globally, colorectal cancer shows a rising incidence among adolescents and young adults, indicating a need for focused interventions.
The average annual percentage change in age-standardized incidence for adolescents with colorectal cancer was 0.37%, while gastric and liver cancers decreased.
Analysis from global disease burden data highlights the trends in digestive system cancers between 1990 and 2021 for adolescents and young adults.
Insights from the study underline the necessity for tailored screening guidelines across varying Social Demographic Index regions.

Zhu et al. (2025) studied this question.

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Cross-sectional study evaluates increasing colorectal cancer burdens in adolescents and young adults, suggesting targeted prevention strategies.