September 11, 2025Open Access

In-situ gelation of a novel hydrogel nanocomposite based on Sodium Alginate/ Sodium Hyaluronate/ Xanthan Gum reinforced with Hydroxyapatite nanoparticles through dual injection of CaCl 2 solution

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The hydrogel scaffold showed significant potential for cell proliferation and regeneration, enhancing bone repair.
Characterization through X-ray diffraction and scanning electron microscopy confirmed its suitable porous structure for cellular adhesion.
The dual injection method minimizes tissue injury while allowing for effective hydrogel application at injury sites.
Cellular assessments revealed promising results in stimulating tissue microenvironments without significant cytotoxicity.

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Implication

This research demonstrates the in-situ gelation of a hydrogel reinforced with hydroxyapatite nanoparticles, suggesting its efficacy in tissue engineering applications.

Cite This Study

Abdouss et al. (2025) studied this question.

synapsesocial.com/papers/68d418cd713b0b5dfea64192 https://doi.org/10.21203/rs.3.rs-7441242/v1

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Implication

This research demonstrates the in-situ gelation of a hydrogel reinforced with hydroxyapatite nanoparticles, suggesting its efficacy in tissue engineering applications.

In-situ gelation of a novel hydrogel nanocomposite based on Sodium Alginate/ Sodium Hyaluronate/ Xanthan Gum reinforced with Hydroxyapatite nanoparticles through dual injection of CaCl 2 solution

Key Points

Discussion

Implication

Cite This Study

In-situ gelation of a novel hydrogel nanocomposite based on Sodium Alginate/ Sodium Hyaluronate/ Xanthan Gum reinforced with Hydroxyapatite nanoparticles through dual injection of CaCl 2 solution

Key Points

Discussion

Implication

Cite This Study

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