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September 11, 2025Chemical and Pharmaceutical BulletinOpen Access

Therapeutic Drug Monitoring Using a Poly(N-isopropylacrylamide) Hydrogel-Modified Bead-Packed Column with an All-Aqueous Mobile Phase without Sample Deproteinization

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Authors

KNKenichi NagaseHiroshima UniversityMKM. KuwabaraThe University of TokyoHKHideko KanazawaKeio University

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Implication

This innovative chromatography method allows safe TDM by separating drugs in serum, suggesting a new approach for monitoring.

Key Points

  • The chromatography column enabled effective separation of drugs from serum proteins at 30°C, enhancing therapeutic drug monitoring.
  • Calibration curves were constructed to accurately quantify drug concentrations, ensuring precise measurement without organic solvents.
  • Using poly(N-isopropylacrylamide) hydrogels modified silica beads, the system remarkably improves the elution behavior of drugs in an aqueous phase.
  • The findings suggest that the TDM method could simplify drug monitoring practices by eliminating the need for sample deproteinization.

Cite This Study

Nagase et al. (2025) studied this question.

synapsesocial.com/papers/68d418cd713b0b5dfea64098https://doi.org/10.1248/cpb.c25-00322
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