Revisiting brown adipose tissue whitening: physiological mechanisms and pathophysiological consequences

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Discussion

This review explores brown adipose tissue whitening and its consequences in obesity, suggesting potential therapeutic strategies.

Whitening of brown adipose tissue is linked to obesity and metabolic disorders, affecting energy expenditure.
Key factors influencing BAT whitening include age, diet, and thermoneutrality, as well as mitochondrial dysfunction.
Interventions such as cold exposure and targeted exercise may mitigate BAT whitening, but mechanisms remain unclear.
Further research is essential to clarify pathogenic mechanisms and improve obesity treatment strategies.

Zhao et al. (2025) studied this question.

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View Full Paper

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Authors

This review explores brown adipose tissue whitening and its consequences in obesity, suggesting potential therapeutic strategies.

Whitening of brown adipose tissue is linked to obesity and metabolic disorders, affecting energy expenditure.
Key factors influencing BAT whitening include age, diet, and thermoneutrality, as well as mitochondrial dysfunction.
Interventions such as cold exposure and targeted exercise may mitigate BAT whitening, but mechanisms remain unclear.
Further research is essential to clarify pathogenic mechanisms and improve obesity treatment strategies.

Zhao et al. (2025) studied this question.

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Bookmark