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September 11, 2025Open Access

Management Strategy for Non‐Responsive and Refractory Celiac Disease in Adults

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AAAbdulbaqi Al‐Toma

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Overview

This review synthesizes diagnostic and treatment strategies for non-responsive and refractory celiac disease, suggesting a structured approach.

Key Points

  • Standardization of care is lacking for non-responsive celiac disease, and dietary assessment is crucial in managing persistent symptoms.
  • Ongoing gluten exposure is a common cause of non-responsive celiac disease, necessitating detection of gluten immunogenic peptides for accurate diagnosis.
  • A systematic diagnostic workup distinguishes between refractory celiac disease types, aiding in selecting appropriate treatment strategies.
  • Effective treatment for refractory celiac disease type I often involves immunomodulators, while type II may require more aggressive approaches and has a worse prognosis.

Cite This Study

Abdulbaqi Al‐Toma (2025) studied this question.

synapsesocial.com/papers/68d418c5713b0b5dfea63f84https://doi.org/10.20944/preprints202509.0919.v1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Management Strategy for Non-Responsive and Refractory Celiac Disease in Adults: A Review Article2025
  2. 2Outcomes in Adults with Celiac Disease Following a Gluten-Free Diet2025 · 4 citations
  3. 3Recent Development in Celiac Disease: Pathophysiology, Animal Models and Treatments2025
  4. 4Persistent Constipation in Patients With Celiac Disease2026
  5. 5Is There a Future Without Gluten Restrictions for Celiac Patients? Update on Current Treatments2025