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September 11, 2025Open Access

BCMA signaling from the Golgi apparatus in B cells

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Authors

BMBenoît ManfroiZCZ. ChemkhiLBLaurie Baert

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Implication

This research reveals BCMA's activity through signaling at the Golgi apparatus in DLBCL, suggesting mechanistic insights into TNF receptor functions.

Key Points

  • BCMA at the Golgi apparatus signals following APRIL binding, and shows impaired activity in DLBCL xenografts.
  • APRIL activates signaling through the NF-κB pathway via BCMA in the Golgi apparatus, crucial for DLBCL development.
  • Ubiquitination and proteosomal degradation of BCMA regulate signaling activity from the Golgi apparatus.
  • This study highlights a novel role for Golgi signaling within the TNF receptor family concerning BCMA.

Cite This Study

Manfroi et al. (2025) studied this question.

synapsesocial.com/papers/68d418c5713b0b5dfea63ebdhttps://doi.org/10.1101/2025.09.10.675116
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