This review uncovers new therapeutic targets and pathways in the tumor microenvironment using advanced single-cell sequencing and spatial transcriptomics.
Key Points
Key pathways like VEGF and PD-1/PD-L1 are crucial in tumor progression and therapy resistance.
Advanced techniques reveal tumor heterogeneity and the cellular interactions within the tumor microenvironment.
Single-cell sequencing captures individual cell profiles, while spatial transcriptomics maps gene expression in tumor tissues.
These methods allow for a deeper understanding of the dynamic networks influencing cancer biology and treatment.