Vaccine Immunity Against Pneumococcus in Children With Sickle Cell Disease: A Retrospective Single-center Study

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Retrospective study assesses vaccination status and booster effects on seroprotection in SCD children.

Booster vaccinations may be needed for optimal seroprotection in children with sickle cell disease, especially after age 5.
Longitudinal analysis indicates a significant decline in pneumococcal seroprotection among SCD patients after vaccinations.
The study reviewed medical records of 42 children with sickle cell disease from 2009 to 2023 for vaccination compliance.
Of the studied children, 81% had complete vaccination records, and 44% received at least one booster dose for immunity.

Noble et al. (2025) studied this question.

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