This research demonstrates the association of lymphatic endothelial cells with prognosis in gastric cancer, suggesting a new model for predicting patient outcomes.
Key Points
The developed prognostic model stratified gastric cancer patients into high- and low-risk groups based on gene expression.
Using an 18-gene signature, the model showed significantly poorer overall survival in high-risk patients compared to low-risk.
Differentially expressed LEC-associated genes were identified through univariate Cox analysis and R package-assisted methods.
The model's clinical utility was underscored by improved prediction accuracy, indicated by the area under the ROC curve.