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September 11, 2025Annals of Neurology

Predictive Value of Plasma Biomarkers in Tau‐PET Transitions

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Authors

JGJonathan Graff‐RadfordJSJeremy A. SyrjanenPVPrashanthi Vemuri

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Overview

Analysis reveals plasma p-tau217 predicts tau-PET conversion, suggesting biomarkers' potential in diagnostics.

Key Points

  • Higher plasma levels of %p-tau217 and amyloid-PET centiloid significantly predicted tau-PET conversion over follow-up.
  • Cox proportional hazards models demonstrated that %p-tau217, along with APS2, were strong predictors in MCSA participants.
  • In the validation cohort, increased %p-tau217 and lower Aβ42/40 also indicated a higher likelihood of tau-PET positivity.
  • These findings imply the potential of plasma biomarkers in assessing the risk of tau-PET transition among older adults.

Cite This Study

Graff‐Radford et al. (2025) studied this question.

synapsesocial.com/papers/68d413ff713b0b5dfea61eechttps://doi.org/10.1002/ana.78003
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