Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 11, 2025Nature ImmunologyOpen Access

Divergent cytokine and transcriptional signatures control functional T follicular helper cell heterogeneity

View Full Paper
Ask AI
Bookmark
Share

Authors

LDLennard DalitCTChin Wee TanASAmania A. Sheikh

Discussion

Loading...

Member takes

Overview

Analysis reveals cytokine-driven TFH heterogeneity, impacting B cell responses during infections and diseases.

Key Points

  • Distinct T follicular helper cell signatures influence B cell responses, enhancing immunity against multiple pathogens.
  • The study identifies cytokine-transcriptional programming crucial for establishing diverse TFH phenotypes, involving type I interferon and TGFβ.
  • Comprehensive profiling of mouse TFH cells across various infections leads to insights into human germinal center responses.
  • New cell surface markers correlate with TFH phenotypes, providing resources for immune monitoring and vaccine development.

Cite This Study

Dalit et al. (2025) studied this question.

synapsesocial.com/papers/68d413f8713b0b5dfea61deehttps://doi.org/10.1038/s41590-025-02258-9
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched one closely related paper. Consider it for comparative context:

  1. 1T Follicular Helper Cells Express a Distinctive Transcriptional Profile, Reflecting Their Role as Non-Th1/Th2 Effector Cells That Provide Help for B Cells2004 · 726 citations