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September 10, 2025The American Journal of Surgical Pathology

SOX2 Is the Most Sensitive Biomarker in Testicular and Gynecologic Embryonic-type Neuroectodermal Tumors (ENT) Based on a Comprehensive Evaluation of Biomarker Expression

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Authors

JWJessica F. WilliamsKGKrzysztof GlomskiTUThomas M Ulbright

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Overview

Evaluation reveals SOX2 as the most sensitive biomarker for embryonic-type neuroectodermal tumors, indicating potential for improved diagnosis.

Key Points

  • SOX2 was identified as the most sensitive biomarker in 85% of embryonic-type neuroectodermal tumors, suggesting a strong link for diagnosis.
  • A combined score was used to categorize the expression of 27 biomarkers in 50 ENTs, with only a few reaching significant levels.
  • Tumors from the testis and gynecologic tract were analyzed for morphologic features and biomarker expression to aid diagnosis of ENTs.
  • Findings indicate that a panel including SOX2, OCT3/4, and others may improve the diagnostic process for neuroectodermal tumors.

Cite This Study

Williams et al. (2025) studied this question.

synapsesocial.com/papers/68d413f8713b0b5dfea61befhttps://doi.org/10.1097/pas.0000000000002466
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