An old leukaemia in young patients—Genetic characteristics of paediatric chronic myeloid leukaemia

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Genomic studies reveal distinct features of paediatric chronic myeloid leukaemia, suggesting unique treatment needs.

Paediatric chronic myeloid leukaemia shows more aggressive clinical features than adult forms.
Genomic studies find unique cytogenetic alterations and higher prevalence of germline variants in children.
Transcriptomic profiling identifies distinct expression signatures in paediatric CML stem cells.
Somatic mutations in specific genes may play a role in diagnosis, though their prognostic significance is still unclear.

Metzler et al. (2025) studied this question.

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