Linear mixed-effects models found interactions between pulse wave velocity and cognitive decline in older adults, highlighting potential risks for amyloid-positive individuals.
Key Points
Interaction between PWV and CSF amyloid positivity indicated faster cognitive decline in executive function.
Higher pulse wave velocity did not relate to cognitive decline outcomes in the sample of 152 older adults.
No significant interaction between PWV and APOE ε4 status was observed with cognitive decline.
Findings suggest arterial stiffness may have an adverse impact on cognitive decline trajectory in amyloid-positive individuals.