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September 10, 2025EP EuropaceOpen Access

Two-year outcomes of left bundle branch area pacing versus traditional right ventricular pacing in middle-aged adults: a registry-based trial

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Authors

MBMatteo BertiniLCLuca CanoviFVFrancesco Vitali

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Overview

Registry-based trial shows left bundle branch area pacing lowers heart failure hospitalizations in middle-aged adults, suggesting better long-term outcomes.

Key Points

  • Left bundle branch area pacing significantly reduced the composite endpoint of cardiovascular death and heart failure hospitalization compared to right ventricular pacing.
  • At two years, the composite endpoint occurred in 6.3% of left bundle branch area pacing patients versus 12.7% in right ventricular pacing patients, indicating a 22% risk reduction.
  • The randomized trial utilized data from the TREEBEARD registry, comparing outcomes between two pacing methods in patients under 65 years old.
  • These findings suggest that while left bundle branch area pacing lowers the risk of heart failure hospitalizations, it does not impact overall mortality compared to right ventricular pacing.

Cite This Study

Bertini et al. (2025) studied this question.

synapsesocial.com/papers/68c243f6b210217d647a9b0dhttps://doi.org/10.1093/europace/euaf181
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