Observational analysis found the single nucleotide variant in SCNN1A increases risk of hypertension, suggesting genetic influence on sodium ion levels.
Key Points
Higher intracellular sodium content was found in hypertension patients carrying the T/T genotype of SCNN1A.
The genetic variant rs11064153 is associated with sodium ion changes, impacting hypertension susceptibility.
Patients with arterial hypertension showed a significant genotype distribution that aligns with Hardy-Weinberg equilibrium.
Assessment of sodium channels provided insights into the genetic predictors of arterial hypertension.