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September 10, 2025Bioscience Biotechnology Research Communications

In silico Evaluation of Plant-Derived Compounds as Potential α-Amylase Inhibitors for Treatment of Type 2 Diabetes

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DKDilip Kothari

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Overview

Molecular docking reveals potent phytochemicals in type 2 diabetes treatment, suggesting new alternatives.

Key Points

  • Top-ranked phytochemical compounds demonstrated binding affinities ranging from -11.7 to -18.6 kcal/mol, surpassing Acarbose.
  • Momordicoside R specifically targets TYR151, spotlighted as the most effective natural α-amylase inhibitor identified.
  • Molecular docking analysis involved 3,320 phytochemicals, highlighting the efficacy of compounds from both Momordica charantia and Azadirachta indica.
  • Results imply phytochemicals could serve as safer alternatives to synthetic drugs, although some face bioavailability challenges.

Cite This Study

Dilip Kothari (2025) studied this question.

synapsesocial.com/papers/68c243f6b210217d647a9311https://doi.org/10.21786/bbrc/18.2.8
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Also Consider

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  1. 1In Silico Evaluation of Anthraquinone Derivatives as Potential α-amylase and α-glucosidase Inhibitors in Diabetes Mellitus2025
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  3. 3Molecular Docking and In Vitro Assessment of <i>Gymnema sylvestre</i> R. Br. and <i>Trigonella foenum‐graecum</i> L. Phytochemicals as Dual α‐Amylase and α‐Glucosidase Inhibitors2025 · 2 citations
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