Implementing TB preventive therapy: lessons from a large-scale initiative in India

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Discussion

Descriptive cohort study assesses 3HP and 6H treatment outcomes in household contacts, highlighting efficacy and safety.

High TPT completion rates were observed for the 3HP regimen, achieving 95% compared to 84% for the 6H regimen.
Adverse event rates were found to be 10% for the 3HP group versus 4% for those receiving 6H during the study period.
This study involved 635 household contacts for 3HP and 24,350 for 6H, highlighting the broad implementation under the JEET project.
Results support the further expansion of the 3HP regimen as an effective preventive therapy option in high-TB-burden regions.

Das et al. (2025) studied this question.

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