September 10, 2025CephalalgiaOpen Access

Exploring medication-overuse and medication-overuse headache in cluster headache

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Discussion

Cross-sectional analysis reveals medication-overuse affects 21% of cluster headache patients, suggesting implications for treatment.

Medication-overuse was found in 21% of the cluster headache participants, indicating significant prevalence.
16% of medication-overusers met the criteria for probable medication-overuse headache as defined by ICHD-3.
Participants with probable medication-overuse headache experienced less effectiveness from acute and preventive treatments.
A conservative definition of medication-overuse significantly lowered the prevalence to 4%, suggesting further research is needed.

Lund et al. (2025) studied this question.

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