Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 10, 2025Chemistry & Biodiversity

Synthesis, Antimicrobial and Antioxidant Activity With ADMET Prediction, Molecular Docking, and Dynamics Studies of Novel Thiazole‐Schiff Base Derivatives

View Full Paper
Ask AI
Bookmark
Share

Authors

RJRownok JahanJagannath UniversitySMSumita Saznin MarufaJagannath UniversityMRMohammad Mostafizur RahmanGazipur Agricultural University

Discussion

Loading...

Member takes

Implication

Synthesis reveals strong antimicrobial activity in thiazole derivatives, suggesting potential for therapeutic use.

Key Points

  • Compound 2b demonstrated the highest antimicrobial activity against Staphylococcus aureus and Salmonella typhi, indicating strong potential.
  • Antioxidant analysis showed compound 2g with an IC50 value of 27.74 µg/mL, outperforming standard ascorbic acid in scavenging ability.
  • Molecular docking indicated moderate binding affinities and stability for compounds 2b, 2e, and 2g, underscoring their potential bioactivity.
  • ADMET properties suggested favorable absorption, distribution, metabolism, and excretion for most derivatives with compound 2k being an exception.

Cite This Study

Jahan et al. (2025) studied this question.

synapsesocial.com/papers/68c243acb210217d647a7e06https://doi.org/10.1002/cbdv.202500888
View Full Paper
Ask AI
Bookmark
Share