September 10, 2025Cancer Genomics & ProteomicsOpen Access

Gene Expression Insights into Cytarabine Resistance in Acute Myeloid Leukemia: The Role of Cytokines

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Study compares gene expression in Cytarabine-resistant HL60 cells, revealing cytokines' impact on overall survival in AML patients.

Resistance to cytarabine is linked to imbalanced cytokine expression in acute myeloid leukemia cells, highlighting treatment challenges.
Twenty-six genes related to cytokine regulation were identified as significantly differing between HL60 and R-HL60 cells.
Results from the Cancer Genome Atlas indicated a correlation between cytokine-related gene expression and overall survival in AML patients.
The findings suggest new targets for overcoming resistance to cytarabine in acute myeloid leukemia, potentially improving patient outcomes.

Lee et al. (2025) studied this question.

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