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September 10, 2025Phytochemical Analysis

Targeted Submetabolome Profiling of Bufadienolides in Venenum Bufonis Using Scheduled Diagnostic Product Ion–Pair Filtering and Substructure Recognition‐Based Strategy

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Authors

ZSZhanpeng ShangWDWei DingZSZhanpeng Shang

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Overview

This research identifies 162 bufadienolides in Venenum bufonis, revealing new compounds and highlighting mass spectrometry advancements.

Key Points

  • A novel targeted submetabolomics strategy identified 162 bufadienolides, significantly expanding known compounds.
  • The strategy achieved a 96% annotation rate, with 155 bufadienolides characterized from Venenum bufonis.
  • This approach utilized mass spectrometry techniques like dynamic exclusion and multiple ion monitoring for enhanced detection.
  • The findings may facilitate future natural product discovery and the understanding of bufadienolides' therapeutic potential.

Cite This Study

Shang et al. (2025) studied this question.

synapsesocial.com/papers/68c243acb210217d647a78c3https://doi.org/10.1002/pca.70025
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