This review shows how genetic and epigenetic factors influence obesity risk, suggesting personalized treatment approaches.
Key Points
Studies reveal that epigenetic factors in adipose tissue contribute to weight regain after fat loss, and emphasize the importance of metabolic memory.
Research indicates that synaptic variants in genes, like BSN and APBA1, affect feeding circuits, highlighting genetic influence on obesity risk.
Novel obesity-related loci have been discovered through genome-wide association studies (GWAS), advancing polygenic risk scores for predicting treatment effectiveness.
Advances in understanding metabolic signaling through neuronal cilia point to the significance of cilia-localized receptors in energy balance and appetite control.