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September 10, 2025Journal of Infection and Public HealthOpen Access

The Outcomes of Cryptococcal Disease in HIV-Positive Individuals Following COVID-19 Infection: A Systematic Review and Meta-Analysis

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Authors

IMIsraa Abdullah MalliSASarah Ali AlqhtaniHAH. Abid

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Overview

Systematic review reveals increased mortality risk and adjusted incidence of cryptococcal disease in PLWHIV post COVID-19, implying urgent need for enhanced surveillance.

Key Points

  • Incidence of cryptococcal disease decreased in HIV-positive individuals after COVID-19 infection, indicating potential impact of COVID-19 on health outcomes.
  • Among 5751 PLWHIV, 130 developed cryptococcosis after COVID-19, suggesting ongoing risks for this vulnerable population despite lower incidence rates.
  • Meta-analysis revealed mortality risk ratio of 1.49 for cryptococcosis in HIV-positive individuals with COVID-19, which raises concerns about long-term outcomes.
  • Findings highlight high heterogeneity in study results, emphasizing the need for targeted strategies and further research on cryptococcal disease management.

Cite This Study

Malli et al. (2025) studied this question.

synapsesocial.com/papers/68c24317b210217d647a5710https://doi.org/10.1016/j.jiph.2025.102941
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