Observational analysis generated the iPSC line UNIONi001-A from HLA-homozygous umbilical cord blood, indicating its potential for cell therapy applications.
The clinical-grade iPSC line UNIONi001-A is derived from HLA-homozygous (HLAh) umbilical cord blood mononuclear cells (CBMCs) of a healthy Han Chinese male neonate. Cells were reprogrammed using episomal plasmids with OCT3/4, SOX2, KLF4, c-MYC and BCL-XL. The iPSCs exhibited typical pluripotent stem cell morphology, expressed pluripotency markers, maintained a normal karyotype, and could differentiate into three germ layers, making them suitable for cell therapy research and clinical use.
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Shi et al. (2025) studied this question.