September 10, 2025VirologyOpen Access

Evaluation of the Effectiveness and Safety of Bacteriophage vB_Sen-Miriam1 Against Salmonella enterica in In Vitro and In Vivo Models

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The bacteriophage vB_Sen-Miriam1 effectively reduced Salmonella counts both extracellularly and intracellularly in model systems.
In the Galleria mellonella larvae model, phage treatment improved larval survival, indicating a lack of toxicity and promising safety profile.
Phage vB_Sen-Miriam1 demonstrated high burst size, stability, and lytic activity against multiple Salmonella strains in both in vitro and in vivo settings.
Genome analysis confirmed the absence of virulence factors and antibiotic resistance genes in phage vB_Sen-Miriam1, highlighting its safety.

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Implication

Evaluation reports the potent antimicrobial effects of bacteriophage vB_Sen-Miriam1 against Salmonella enterica, suggesting promising therapeutic implications.

Cite This Study

Knefel et al. (2025) studied this question.

synapsesocial.com/papers/68c242e0b210217d647a4dfc https://doi.org/10.1016/j.virol.2025.110660

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Implication

Evaluation reports the potent antimicrobial effects of bacteriophage vB_Sen-Miriam1 against Salmonella enterica, suggesting promising therapeutic implications.

Evaluation of the Effectiveness and Safety of Bacteriophage vB_Sen-Miriam1 Against Salmonella enterica in In Vitro and In Vivo Models

Key Points

Discussion

Implication

Cite This Study

Evaluation of the Effectiveness and Safety of Bacteriophage vB_Sen-Miriam1 Against Salmonella enterica in In Vitro and In Vivo Models

Key Points

Discussion

Implication

Cite This Study