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September 10, 2025Natural Product Research

Enhancing the anti-inflammatory efficacy of polysaccharides through processing techniques: a case study on Atractylodes macrocephala

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Authors

HXHong-Da XuanSSSheng-Nan ShenCFChunjin Fu

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Overview

This study demonstrates improved anti-inflammatory effects and insulin sensitivity in Atractylodes macrocephala polysaccharides, indicating traditional processing techniques enhance therapeutic outcomes.

Key Points

  • ABZP exhibited stronger anti-inflammatory effects compared to BZP, enhancing therapeutic outcomes from processing.
  • Increased polysaccharide yield after AFI processing, with minimal changes to molecular weight and structure.
  • Mechanistic studies revealed modulation of PI3K/Akt and NF-κB pathways improving anti-inflammatory responses.
  • Proteomic analysis indicated ABZP induces a safer molecular response compared to unprocessed polysaccharides.

Cite This Study

Xuan et al. (2025) studied this question.

synapsesocial.com/papers/68c242e0b210217d647a4a1ehttps://doi.org/10.1080/14786419.2025.2548615
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