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September 10, 2025AgingOpen Access

DNMT1-mediated SPINT2 expression drives early senescence by suppressing c-Met signaling in human fibroblasts

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Authors

MSMin Seok SimHBHae-Ok ByunSMSeongki Min

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Overview

This research reveals DNMT1's role in suppressing c-Met signaling and driving cellular senescence via SPINT2 expression.

Key Points

  • Downregulation of dnmt1 triggers early cellular senescence through spint2 manipulation.
  • Pharmacological inhibition of dnmt1 leads to increased spint2 expression and induced senescence.
  • Transcriptomic profiling highlights 17 deregulated genes in c-Met signaling related to senescence.
  • Findings suggest dnmt1-mediated spint2 regulation as a novel mechanism for targeting aging-related diseases.

Cite This Study

Sim et al. (2025) studied this question.

synapsesocial.com/papers/68c242e0b210217d647a49b9https://doi.org/10.18632/aging.206303
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