September 10, 2025Brain ResearchOpen Access

Hypoxia-related gene expression in major depressive disorder: identifying diagnostic biomarkers and implications for immune cell infiltration

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Authors

RPRan Pan YYYan Yang QKQinghuo Kong

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Implication

This study identifies hypoxia-related differentially expressed genes and assesses immune cell infiltration in major depressive disorder, suggesting diagnostic biomarkers.

Key Points

Hypoxia-related differentially expressed genes may serve as diagnostic biomarkers for major depressive disorder, highlighting their clinical relevance.
The analysis identified 474 differentially expressed genes, including 22 hypoxia-related differentially expressed genes with implications for immune dysfunction.
Using gene ontology and KEGG pathway analyses, key biological processes involved in hypoxic responses were elucidated, providing insights into MDD mechanisms.
Immune infiltration analysis revealed correlations between gene expression and specific immune cell types, suggesting immune system involvement in major depressive disorder.

Cite This Study

Pan et al. (2025) studied this question.

synapsesocial.com/papers/68c242e0b210217d647a46cf https://doi.org/10.1016/j.brainres.2025.149866

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Implication

This study identifies hypoxia-related differentially expressed genes and assesses immune cell infiltration in major depressive disorder, suggesting diagnostic biomarkers.

Hypoxia-related gene expression in major depressive disorder: identifying diagnostic biomarkers and implications for immune cell infiltration

Discussion

Member takes

Implication

Key Points

Cite This Study

Hypoxia-related gene expression in major depressive disorder: identifying diagnostic biomarkers and implications for immune cell infiltration

Discussion

Member takes

Implication

Key Points

Cite This Study

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