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September 10, 2025Scientific ReportsOpen Access

Prevalence and determinants of antidepressant non-adherence among patients with major depressive disorder in Ethiopia: a multi-center cross sectional study

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Authors

GCGashaw Sisay ChanieEBEyayaw Ashete BelachewLLLiknaw Workie Limenh

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Overview

Cross-sectional survey assesses antidepressant non-adherence in patients with major depressive disorder, highlighting risk factors.

Key Points

  • Antidepressant non-adherence was prevalent at 32.9%, impacting treatment outcomes severely.
  • Female gender, unemployment, illiteracy, long treatment duration, and severe adverse drug reactions increased non-adherence risk.
  • Multivariate logistic regression was employed to identify determinants of non-adherence, yielding significant odds ratios for several factors.
  • The findings suggest a critical need for targeted interventions to enhance adherence in high-risk populations.

Cite This Study

Chanie et al. (2025) studied this question.

synapsesocial.com/papers/68c2427db210217d647a41f3https://doi.org/10.1038/s41598-025-15102-9
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