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September 10, 2025Journal of Applied Polymer Science

Fabrication and Evaluation of Pemetrexed Disodium Transdermal Patches Using a DoE Approach

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Authors

TYTejpal YadavHYHemant Kumar Singh YadavRGRitu Gilhotra

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Overview

This study demonstrates the efficacy of transdermal drug delivery for pemetrexed disodium, suggesting improved management of autoimmune diseases.

Key Points

  • Pemetrexed disodium-loaded patches showed sustained drug release, reducing systemic side effects for autoimmune treatment.
  • Optimal formulations OF4 and OF5 demonstrated superior drug release efficiency and favorable mechanical properties.
  • Transdermal patches were fabricated using hydrophilic polymers and characterized using several in vitro analyses.
  • Significant implications arise for clinical applications in managing diseases like psoriasis, pending further validation.

Cite This Study

Yadav et al. (2025) studied this question.

synapsesocial.com/papers/68c24236b210217d647a31f1https://doi.org/10.1002/app.57618
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