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September 10, 2025ImmunogeneticsOpen Access

Dysregulation of lncRNAs in NK cells from breast cancer patients: implications for NK cell functions

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Authors

MRMona RadyEMEman A. MohamedOKOla Khorshid

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Overview

This investigation reveals altered gene expression in nk cells from breast cancer patients, suggesting implications for immune surveillance.

Key Points

  • Dysregulated lncRNAs in nk cells impact their antitumor functions, leading to potential immune evasion.
  • Twenty-six lncRNAs were found to be differentially expressed, with 10 downregulated and 16 upregulated in patients.
  • Functional analysis shows downregulated lncRNAs are key in chromatin organization and epigenetic regulation.
  • Understanding lncRNA dysregulation in nk cells may enhance therapeutic strategies for breast cancer.

Cite This Study

Rady et al. (2025) studied this question.

synapsesocial.com/papers/68c24236b210217d647a2dddhttps://doi.org/10.1007/s00251-025-01383-x
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