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September 10, 2025Journal of Innovations in Cardiac Rhythm ManagementOpen Access

Direct Oral Anticoagulants Versus Vitamin K Antagonists in Patients with Atrial Fibrillation and Bioprosthetic Valve Replacement: An Umbrella Review

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Authors

AKAlina Sami KhanALAbdullah LnuZAZain Ul Abideen

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Overview

Umbrella review shows direct oral anticoagulants reduce mortality and bleeding risks in patients with atrial fibrillation and bioprosthetic valve replacement, indicating better safety profiles.

Key Points

  • Direct oral anticoagulants lower all-cause mortality and bleeding risks compared to vitamin K antagonists in atrial fibrillation patients after valve surgery.
  • The pooled analysis demonstrated a risk ratio of 0.95 for all-cause mortality and 0.73 for major/life-threatening bleeding with direct oral anticoagulants.
  • The study utilized an umbrella review methodology that included 20 systematic reviews and meta-analyses of randomized controlled trials and observational studies.
  • Results suggest that direct oral anticoagulants may serve as more favorable alternatives to vitamin K antagonists, offering efficacy without the need for continuous monitoring.

Cite This Study

Khan et al. (2025) studied this question.

synapsesocial.com/papers/68c241efb210217d647a203dhttps://doi.org/10.19102/icrm.2025.16075
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Valve-Specific Comparative Effectiveness of Direct Oral Anticoagulants Versus Vitamin K Antagonists After Surgical Valve Procedures in Atrial Fibrillation: A Systematic Review and Meta-Analysis2026
  2. 2Direct oral anticoagulants versus vitamin K antagonists after left atrial appendage occlusion: a systematic review and meta-analysis2026
  3. 3Evaluating the Efficacy and Safety of Direct Oral Anticoagulants Compared to Vitamin K Antagonists in Patients with Antiphospholipid Syndrome: Updated Systematic Review and Meta-Analysis2025
  4. 4Direct oral anticoagulants versus vitamin K antagonists in concurrent hypertrophic cardiomyopathy and atrial fibrillation: a meta-analysis2025
  5. 5Comparison of Safety and Effectiveness Between Direct Oral Anticoagulants and Vitamin K Antagonists in Dementia Patients with Atrial Fibrillation: A Systematic Review and Meta-Analysis.2025 · 1 citations