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September 10, 2025

Unraveling the enigma of mental disorders: a genetics-first approach and the role of mouse models based on rare disease-susceptible genome variants.

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Authors

RKReon KondoDMDaisuke MoriHWHiroaki Wake

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Overview

Review highlights mouse models' role in revealing genetic variants linked to mental disorders, suggesting innovative research pathways.

Key Points

  • Mouse models reveal critical genetic links to mental disorders, emphasizing the role of rare variants in disease mechanisms.
  • Emerging data show that genomic variants, such as copy number and single nucleotide variations, significantly influence mental disorder pathogenesis.
  • Assessment combines genetic variants with phenotypic outcomes, using advanced technologies like optogenetics for deeper insights.
  • These findings support a comprehensive strategy to study mental disorders and guide future therapeutic approaches.

Cite This Study

Kondo et al. (2025) studied this question.

synapsesocial.com/papers/68c241efb210217d647a2002https://doi.org/10.18999/nagjms.87.2.196
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