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September 10, 2025AntibioticsOpen Access

Ceftazidime-Avibactam for the Treatment of Carbapenem-Resistant Organisms: A Prospective, Observational, Single-Center Study

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Authors

FPFrieder PfäfflinATAnja TheloeMSMiriam Stegemann

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Overview

Observational study finds clinical cure in 59% of patients with carbapenem-resistant organisms, highlighting treatment potential.

Key Points

  • Clinical cure achieved in 59% of patients at 14 days, indicating effectiveness of ceftazidime-avibactam.
  • Nine percent of patients experienced death and four percent showed microbiological failure, underscoring treatment challenges.
  • Observational analysis of 50 critically ill patients treated with ceftazidime-avibactam for carbapenem-resistant infections.
  • Findings support careful prescription of ceftazidime-avibactam, suggesting it may effectively address resistant infections.

Cite This Study

Pfäfflin et al. (2025) studied this question.

synapsesocial.com/papers/68c241efb210217d647a1422https://doi.org/10.3390/antibiotics14080773
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Pharmacokinetics/Pharmacodynamics and Therapeutic Drug Monitoring of Ceftazidime/Avibactam in Patients With Gram‐Negative Bacterial Infections2025
  2. 2Ceftazidime–Avibactam in Critically Ill Patients: A Multicenter Observational Study2025
  3. 3Impact of ceftazidime-avibactam on mortality in bloodstream infections: a cohort study in patients with acute leukemia.2025
  4. 4A Comparative Study of Ceftazidime–Avibactam and Meropenem-Based Regimens in the Treatment of Carbapenem-Resistant Gram-Negative Bacterial Infections in Intensive Care Units2025
  5. 5[Translated article] Influence of SARS-CoV-2 infection on the use of ceftazidime-avibactam in the critical patient2025