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September 10, 2025iScienceOpen Access

Analysis of chromatin accessibility associated with azacitidine response in higher-risk myelodysplastic neoplasms

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Authors

DKDayoung KimSPSilvia ParkYKYong-Rim Kwon

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Overview

Analysis reveals chromatin accessibility impacts the efficacy of azacitidine in myelodysplastic neoplasms, indicating immune cell function's role.

Key Points

  • Distinct chromatin accessibility patterns are associated with azacitidine response in patients.
  • Chromatin-accessible regions in non-responders were enriched for myeloid progenitor signatures.
  • CD8+ T cells in non-responders showed reduced chromatin accessibility at key binding sites.
  • These findings suggest chromatin accessibility may help predict responses to hypomethylating agents.

Cite This Study

Kim et al. (2025) studied this question.

synapsesocial.com/papers/68c241acb210217d647a0ba1https://doi.org/10.1016/j.isci.2025.113297
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