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September 10, 2025Journal of Integrative NeuroscienceOpen Access

Effect of Hyperbaric Oxygen Treatment on Lipid Metabolism and Neurovascular Microenvironment in an Apolipoprotein E Knockout Mouse Model

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Authors

GDGuoying DongYLYuxiao LiuHLHuijun Liu

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Overview

Observational analysis shows HBO treatment enhances lipid metabolism and reduces neurodegeneration in ApoE-deficient mice, suggesting therapeutic potential.

Key Points

  • HBO treatment significantly reversed cognitive decline in ApoE-/- mice, indicating an improvement in cognitive function.
  • The blood lipid profiles showed improvement and reduced body weight in ApoE-/- mice after HBO treatment.
  • Neuronal injury and amyloid-β deposition were lowered due to HBO therapy, suggesting a protective effect.
  • Reduction of inflammatory factors and oxidative stress after HBO treatment highlights its neuroprotective properties.

Cite This Study

Dong et al. (2025) studied this question.

synapsesocial.com/papers/68c241acb210217d647a07d5https://doi.org/10.31083/jin39656
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