September 10, 2025NeuroImageOpen Access

Impaired glymphatic transport in hypoxic-ischemic encephalopathy

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HIE results in significantly impaired glymphatic transport dynamics in neonatal mice, affecting brain regions and function.
Dynamic contrast-enhanced MRI revealed prolonged tracer enhancement and retention in specific brain areas due to HIE.
Quantitative analysis showed substantial reductions in CSF-to-perivascular and perivascular-to-parenchyma transfer constants.
Astrocytic AQP4 mis-polarization correlates with glymphatic dysfunction, highlighting its importance for glymphatic system integrity.

Authors

JSJian‐Wei ShenUniversity of Science and Technology of China YYYing YangCentral South University FCFangfang ChenWeifang Medical University

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Implication

This study finds impaired glymphatic function in neonatal mice with hypoxic-ischemic encephalopathy, indicating a critical relationship with AQP4 polarization.

Cite This Study

Shen et al. (2025) studied this question.

synapsesocial.com/papers/68c2416eb210217d6479faee https://doi.org/10.1016/j.neuroimage.2025.121414

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Implication

This study finds impaired glymphatic function in neonatal mice with hypoxic-ischemic encephalopathy, indicating a critical relationship with AQP4 polarization.

Impaired glymphatic transport in hypoxic-ischemic encephalopathy

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Discussion

Implication

Cite This Study

Impaired glymphatic transport in hypoxic-ischemic encephalopathy

Key Points

Discussion

Implication

Cite This Study

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