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September 10, 2025Journal of Advanced ResearchOpen Access

Elevated lactate production exacerbates PM2.5-induced pulmonary fibrosis by stabilizing TGF-β1

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Authors

ZLZhihao LiuWLWei LiuHWHuaiqing Wei

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Implication

Observational analysis shows lactate exacerbates pulmonary fibrosis via TGF-β1 in macrophages, suggesting new therapeutic targets.

Key Points

  • Elevated lactate in macrophages enhances TGF-β1 secretion, worsening pulmonary fibrosis.
  • Macrophages produced increased lactate during PM2.5 exposure, correlating with fibrosis severity.
  • Immunoprecipitation revealed that lactate stabilizes TGF-β1 by inhibiting CHIP expression.
  • Inhibiting lactate production alleviated fibrosis symptoms in exposed mice, indicating potential treatments.

Cite This Study

Liu et al. (2025) studied this question.

synapsesocial.com/papers/68c2416eb210217d6479f9f2https://doi.org/10.1016/j.jare.2025.07.057
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