Review highlights challenges in transplant eligibility and donor selection for older patients, indicating evolving practices for hematological malignancies.
Key Points
Increased use of allogeneic transplantation has been observed in patients aged ≥ 70 with hematological malignancies, reflecting changing eligibility criteria.
Evidence shows that reduced-intensity conditioning is generally recommended for older patients, helping to reduce transplant-related complications.
Assessing eligibility also involves evaluating health status, comorbidities, and cognitive function to predict non-relapse mortality effectively.
Choosing the right donor is crucial, with matched related or younger unrelated donors preferred, though options are expanding with haploidentical donors.