September 10, 2025CureusOpen Access

The Role of Dupilumab in Atopic Dermatitis-Like Graft-Versus-Host Disease

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Discussion

Case report illustrates dupilumab's clinical improvement in pediatric AD-like GVHD, highlighting potential benefits over corticosteroids.

Dupilumab significantly improved symptoms in a pediatric patient with AD-like GVHD.
Corticosteroids and immunosuppressants showed limited effectiveness and adverse effects.
Off-label dupilumab treatment allowed for corticosteroid tapering, enhancing the patient's quality of life.
Further studies are suggested to fully evaluate dupilumab's long-term safety and efficacy.

Costa et al. (2025) studied this question.

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