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September 10, 2025International Journal of Research in Pharmacology & Pharmacotherapeutics

Exploring the Adaptogenic Power of Withania somnifera: Mechanisms of Stress Alleviation and Implications for Mental Health and Wellness

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Authors

GMG. MamathaNANisha AravindPKP Krishna

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Overview

This review uncovers withania somnifera's adaptogenic effects in stress alleviation, indicating its evolving role in mental health management.

Key Points

  • Withania somnifera significantly reduces cortisol levels and alleviates anxiety, supporting mental health.
  • Clinical evidence shows its efficacy in improving cognitive function and reducing symptoms of depression.
  • The adaptogen's effects are mediated through the regulation of the hypothalamic-pituitary-adrenal axis and neurotransmitter pathways.
  • Ongoing challenges in standardizing formulations highlight the need for further research on optimal dosages.

Cite This Study

Mamatha et al. (2025) studied this question.

synapsesocial.com/papers/68c2416eb210217d6479ea30https://doi.org/10.61096/ijrpp.v14.iss1.2025.139-145
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Withania somnifera: A Comprehensive Review of Its Pharmacological Properties, Therapeutic Applications, and Mechanisms of Action2025
  2. 2Attenuation Effect of Withania somnifera Extract on Restraint Stress-Induced Anxiety-like Behavior and Hippocampal Alterations in Mice2025
  3. 3Pharmacological Investigation of Withania somnifera: A Neuropharmacological Study in Rats2025
  4. 4Effectiveness of Withania somnifera (Ashwagandha) in prevention of Cancer: A Systematic Review2025
  5. 5Withania somnifera : A Remarkable Herb to Improve Animal Fertility2025