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September 10, 2025Heart RhythmOpen Access

Left Atrial Appendage Closure versus Oral Anticoagulation for Stroke Prevention in Atrial Fibrillation: Long-Term Outcomes from Four Randomized Trials

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Authors

WKWulamiding KaisaierZXZixuan XuLGLinjuan Guo

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Overview

Meta-analysis shows lower risks of death and hemorrhagic stroke with left atrial appendage closure versus oral anticoagulation.

Key Points

  • Left atrial appendage closure significantly reduces all-cause death risks when compared with oral anticoagulation.
  • Patients who received left atrial appendage closure had lower hemorrhagic stroke risks, with an RR of 0.34.
  • The analysis was a systematic assessment of randomized controlled trials with 3,116 atrial fibrillation patients.
  • These findings suggest considering left atrial appendage closure as an alternative to oral anticoagulation for specific patients.

Cite This Study

Kaisaier et al. (2025) studied this question.

synapsesocial.com/papers/68c24126b210217d6479e519https://doi.org/10.1016/j.hrthm.2025.07.051
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