September 10, 2025Clinica Chimica ActaOpen Access

Blood collected on dry blood spots is fit for newborn screening of sickle cell disease (SCD) by different analytical systems

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The detection of hemoglobin S in dried blood spots was highly reproducible across various analytical systems, indicating reliable newborn screening.
All analytical methods correctly classified samples for sickle cell disease screening despite minor discrepancies in fetal hemoglobin levels.
Samples spiked at three hemoglobin S concentrations were analyzed across three timepoints, showing consistent results within set thresholds.
These findings support implementing dried blood spots in low-resource settings for effective newborn screening and highlight the need for Hb F quantification standardization.

Authors

RPRenata PaleariUniversity of Verona MVMatteo VidaliFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico RRRoberta RollaUniversità degli Studi del Piemonte Orientale “Amedeo Avogadro”

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Implication

This analysis confirms dried blood spots' effectiveness in hemoglobin S quantification for sickle cell disease screening, suggesting improved diagnostic consistency.

Cite This Study

Paleari et al. (2025) studied this question.

synapsesocial.com/papers/68c24126b210217d6479e4e2 https://doi.org/10.1016/j.cca.2025.120528

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Implication

This analysis confirms dried blood spots' effectiveness in hemoglobin S quantification for sickle cell disease screening, suggesting improved diagnostic consistency.

Blood collected on dry blood spots is fit for newborn screening of sickle cell disease (SCD) by different analytical systems

Key Points

Discussion

Implication

Cite This Study

Blood collected on dry blood spots is fit for newborn screening of sickle cell disease (SCD) by different analytical systems

Key Points

Discussion

Implication

Cite This Study