September 10, 2025Journal of Clinical MedicineOpen Access

Enhanced Diagnostic Accuracy for Septic Arthritis Through Multivariate Analysis of Serum and Synovial Biomarkers

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Multivariate analysis enhances diagnostic accuracy for septic arthritis using biomarkers like CRP and PTX3.

The hyaluronic acid test improved diagnostic accuracy for septic arthritis by integrating multiple biomarkers, maximizing sensitivity.
Among single biomarkers, synovial WBC led with an AUC of 0.837, showing significant potential for diagnostic use.
Combining serum CRP and synovial WBC boosted diagnostic accuracy with 100% sensitivity, while adding novel biomarkers enhanced performance further.
The study highlights PTX3's utility in ruling out septic arthritis due to its high sensitivity and negative predictive value.

Park et al. (2025) studied this question.

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