Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 10, 2025Siberian Journal of OncologyOpen Access

Contemporary insights into the molecular mechanisms of development and genetic susceptibility to pancreatic cancer

View Full Paper
Ask AI
Bookmark
Share

Authors

ASA. D. SperidonovaAZAliya ZaripovaIGI. R. Gilyazova

Discussion

Loading...

Member takes

Implication

Literature review reveals genetic variants linked to pancreatic cancer risk, highlighting oncogene activation.

Key Points

  • Approximately 10% of pancreatic adenocarcinoma patients have germinal pathogenic variants linked to increased PC risk.
  • These variants largely occur in genes responsible for DNA damage repair, affecting disease outcome.
  • Tumor cells exhibit complex multistep genetic alterations, leading to oncogene activation and cancer progression.
  • Identifying genetic alterations can help tailor targeted drug therapy for specific patient groups.

Cite This Study

Speridonova et al. (2025) studied this question.

synapsesocial.com/papers/68c24126b210217d6479df0bhttps://doi.org/10.21294/1814-4861-2025-24-3-149-161
View Full Paper
Ask AI
Bookmark
Share