September 10, 2025CureusOpen Access

Synchronous Human Papillomavirus (HPV)-Positive Oropharyngeal Carcinoma and Occult Papillary Thyroid Carcinoma: A Case Report and Review of the Literature

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A 52-year-old female was diagnosed with HPV-associated oropharyngeal carcinoma and occult thyroid carcinoma simultaneously.
Initial evaluations revealed cervical lymphadenopathy, but further tests identified metastatic lymph nodes from undiagnosed thyroid cancer.
Careful pathological evaluation is essential in diagnosing multiple primary tumors in patients with cervical lymph nodes.
This case illustrates the rarity of synchronous malignancies affecting the oropharynx and thyroid gland, emphasizing the need for thorough assessments.

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Case report details concurrent oropharyngeal carcinoma with occult thyroid carcinoma, highlighting evaluation challenges.

Tai et al. (2025) studied this question.

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