Causal Relationships Between Modifiable Risk Factors and Gastroesophageal Reflux Disease: A Two-Sample Mendelian Randomization Study

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Mendelian randomization analysis indicates obesity traits significantly impact the risk of GERD.
Key factors such as sleep apnea syndrome and negative emotions were linked to increased GERD risk.
Longer sleep duration was associated with reduced risk, highlighting the role of sleep in digestive health.
The findings underscore unique contributions of body fat distribution and mental health on GERD incidence.

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Two-sample mendelian randomization identifies multiple modifiable risk factors linked to GERD, suggesting new prevention strategies.

Zhou et al. (2025) studied this question.

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