Novel 1,2,3-triazole derivatives show significant antiproliferative activity against cancer cells, highlighting their ADME properties and kinase interactions.
Key Points
Compounds 3 and 29 exhibited the highest antiproliferative activity against various human cancer cell lines.
Predicted pharmacokinetic properties indicate high gastrointestinal absorption and low blood-brain barrier permeability.
Molecular docking revealed strong binding affinities of compounds for kinases TAO2 and c-Src.
This work provides a foundation for further development of 1,2,3-triazole derivatives as potential anticancer agents.